Cart
sales@molnova.com
PFI-90
CAS No. 53995-62-3
PFI-90( 2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide )
Catalog No. M24526 CAS No. 53995-62-3
PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action.PFI-90 has the potential for the antitumor activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 31 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePFI-90
-
NoteResearch use only, not for human use.
-
Brief DescriptionPFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action.PFI-90 has the potential for the antitumor activity.
-
DescriptionPFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action.PFI-90 has the potential for the antitumor activity. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased.
-
In VitroWestern Blot Analysis Cell Line:RH4 and SCMC cells Concentration:3 μΜ Incubation Time:24 hours Result:Apoptosis increased in RH4 and SCMC cells.
-
In Vivo——
-
Synonyms2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide
-
PathwayChromatin/Epigenetic
-
TargetHistone Demethylase
-
RecptorRH4/RH30/OSA-CL/TC-32
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number53995-62-3
-
Formula Weight214.22
-
Molecular FormulaC11H10N4O
-
Purity>98% (HPLC)
-
SolubilityDMSO: 40mg/mL?(186.72. mM);H2O: insoluble;Ethanol: 20mg/mL?(93.36 mM;?Need ultrasonic and warming)
-
SMILESO=C(C1=NC=CC=C1)NNC2=NC=CC=C2
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.KHAN, Javed, et al. Inhibitors of histone demethylases (pfi-63 and pfi-90) for the treatment of cancer and for the inhibition of histone demethylase in cells. WO2021101929A1.
molnova catalog
related products
-
JIB-04
JIB-04 is a pan-selective Jumonji histone demethylase inhibitor.
-
SGC-iMLLT
SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class chemical probe displaying cellular target engagement of MLLT1(Kd = 0.129?μM) and MLLT3(Kd = 0.077?μM).
-
SD-70
A small molecule tumor translocation inhibitor that inhibits the prostate cancer cell transcriptional program.
