Stauprimide

CAS No. 154589-96-5?

Stauprimide( N-Benzoyl-7-oxo Staurosporine )

Catalog No. M12193 CAS No. 154589-96-5?

A staurosporine analog that promotes embryonic stem cell (ESC) differentiation by inhibiting nuclear localization of the MYC transcription factor NME2.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Stauprimide
  • Note
    Research use only, not for human use.
  • Brief Description
    A staurosporine analog that promotes embryonic stem cell (ESC) differentiation by inhibiting nuclear localization of the MYC transcription factor NME2.
  • Description
    A staurosporine analog that promotes embryonic stem cell (ESC) differentiation by inhibiting nuclear localization of the MYC transcription factor NME2, which in turn results in down-regulation of MYC transcription; increases the efficiency of mouse and human embryonic stem cell differentiation in conjunction with lineage specification cues with EC50 of 0.3 uM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    N-Benzoyl-7-oxo Staurosporine
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    c-Myc
  • Recptor
    c-Myc
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    154589-96-5?
  • Formula Weight
    584.6
  • Molecular Formula
    C35H28N4O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(=O)NC6=O)N(C)C(=O)C9=CC=CC=C9)OC
  • Chemical Name
    N-((5R,7R,8R,9S)-8-methoxy-9-methyl-14,16-dioxo-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-methylbenzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bouvard C, et al. Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3497-3502. 2. Zhu S, et al. Cell Stem Cell. 2009 May 8;4(5):416-26. 3. Tahamtani Y, et al. Stem Cells Dev. 2013 May 1;22(9):1419-32.
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