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Home - Products - Cell Cycle/DNA Damage - c-Myc - 10058-F4

10058-F4

CAS No. 403811-55-2

10058-F4( 10058-F4 | 10058F4 | 10058 F4 )

Catalog No. M14382 CAS No. 403811-55-2

10058-F4 is a specific c-Myc inhibitor that disrupts the association between the c-Myc and Max.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    10058-F4
  • Note
    Research use only, not for human use.
  • Brief Description
    10058-F4 is a specific c-Myc inhibitor that disrupts the association between the c-Myc and Max.
  • Description
    10058-F4 is a specific c-Myc inhibitor that disrupts the association between the c-Myc and Max, inhibits HL60 cell growth with IC50 of 51 uM; arrests AML cells at G0/G1 phase, downregulates c-Myc expression and upregulates CDK inhibitors p21 and p27; induces apoptosis through activation of mitochondrial pathway shown by downregulation of Bcl-2, upregulation of Bax, release of cytoplasmic cytochrome C, and cleavage of caspase 3, 7, and 9; also induces myeloid differentiation.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    10058-F4 | 10058F4 | 10058 F4
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    c-Myc
  • Recptor
    c-Myc-MAX
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    403811-55-2
  • Formula Weight
    249.3518
  • Molecular Formula
    C12H11NOS2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 41 mg/mL
  • SMILES
    O=C1NC(S/C1=C/C2=CC=C(CC)C=C2)=S
  • Chemical Name
    4-Thiazolidinone, 5-[(4-ethylphenyl)methylene]-2-thioxo-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Huang MJ, et al. Exp Hematol. 2006 Nov;34(11):1480-9. 2. Lin CP, et al. Anticancer Drugs. 2007 Feb;18(2):161-70. 3. Wang H, et al. Mol Cancer Ther. 2007 Sep;6(9):2399-408. 4. Guo J, et al. Cancer Chemother Pharmacol. 2009 Mar;63(4):615-25.
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