Splitomicin

CAS No. 5690-03-9

Splitomicin( Splitomicin )

Catalog No. M17730 CAS No. 5690-03-9

Splitomicin (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 37 In Stock
10MG 51 In Stock
25MG 105 In Stock
50MG 164 In Stock
100MG 309 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Splitomicin
  • Note
    Research use only, not for human use.
  • Brief Description
    Splitomicin (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.
  • Description
    Splitomicin is a cell-permeable lactone derived from naphthol and known to be a potent selective inhibitor of Sir2 (silent information regulator 2) and HDAC. Splitomicin inhibits the NAD+-dependent deacetylase activity of Sir2 in vitro. It increases the levels of cyclic AMP by inhibiting the activity of cyclic AMP phosphodiesterase, interferes with mobilization of intracellular Ca+2 and ATP release.
  • In Vitro
    Cell Proliferation Assay Cell Line:Human breast cancer MCF-7 and lung cancer H1299 cells Concentration:10, 33, 100, and 333 μM Incubation Time:24 hours Result:Inhibited colony formation in a dose-dependent manner.
  • In Vivo
    Animal Model:C57BL/6 mice aged 12-14 weeks weighing on average 27 g Dosage:80 mg/kg Administration:Intraperitoneal injection every 24 h for 5 days Result:Increased TF activity in mouse carotid artery as compared with the controls.
  • Synonyms
    Splitomicin
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PI3K
  • Recptor
    SIRT2p
  • Research Area
    Cardiovascular Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    5690-03-9
  • Formula Weight
    198.22
  • Molecular Formula
    C13H10O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (504.49 mM)
  • SMILES
    O=C1CCc2c3ccccc3ccc2O1
  • Chemical Name
    1H-benzo[f]chromen-3(2H)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bedalov A, et al. Proc Natl Acad Sci U S A. 2001, 98(26), 15113-15118.
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