Cart
sales@molnova.com
SGI-1027
CAS No. 1020149-73-8
SGI-1027( SGI1027 | SGI 1027 )
Catalog No. M10094 CAS No. 1020149-73-8
SGI-1027 (SGI1027) is a potent inhibitor of DNA methyltransferase (DNMT) with IC50s of 6-12.5 uM for DNMT1, DNMT3A, and DNMT3B.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 48 | In Stock |
|
| 10MG | 86 | In Stock |
|
| 25MG | 149 | In Stock |
|
| 50MG | 281 | In Stock |
|
| 100MG | 443 | In Stock |
|
| 500MG | 981 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSGI-1027
-
NoteResearch use only, not for human use.
-
Brief DescriptionSGI-1027 (SGI1027) is a potent inhibitor of DNA methyltransferase (DNMT) with IC50s of 6-12.5 uM for DNMT1, DNMT3A, and DNMT3B.
-
DescriptionSGI-1027 (SGI1027) is a potent inhibitor of DNA methyltransferase (DNMT) with IC50s of 6-12.5 uM for DNMT1, DNMT3A, and DNMT3B; induces selective degradation of DNMT1 with minimal or no effects on DNMT3A and DNMT3B in different cancer cell lines.
-
In Vitro——
-
In Vivo——
-
SynonymsSGI1027 | SGI 1027
-
PathwayChromatin/Epigenetic
-
TargetDNMT
-
RecptorDNMT1|DNMT3A|DNMT3B
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number1020149-73-8
-
Formula Weight461.5178
-
Molecular FormulaC27H23N7O
-
Purity>98% (HPLC)
-
SolubilityDMSO: 27 mg/mL
-
SMILESO=C(NC1=CC=C(NC2=NC(N)=NC(C)=C2)C=C1)C3=CC=C(NC4=CC=NC5=CC=CC=C45)C=C3
-
Chemical NameBenzamide, N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Datta J, et al. Cancer Res. 2009 May 15;69(10):4277-85.
2. Rilova E, et al. ChemMedChem. 2014 Mar;9(3):590-601.
molnova catalog
related products
-
AA-CW236
A potent, selective, non-pseudosubstrate inhibitor of O(6) -alkylguanine DNA methyltransferase (MGMT) with low-nanomolar potency.
-
Dacogen
Decitabine is indicated for treatment of patients with myelodysplastic syndrome (MDS).
-
RG108
RG108 is an inhibitor of DNA methyltransferase with IC50 of 115 nM in a cell-free assay, does not cause trapping of covalent enzymes.
