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SBI-115
CAS No. 882366-16-7
SBI-115( —— )
Catalog No. M20784 CAS No. 882366-16-7
SBI-115 is an?antagonist of?TGR5.?SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 43 | In Stock |
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| 10MG | 67 | In Stock |
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| 25MG | 133 | In Stock |
|
| 50MG | 209 | In Stock |
|
| 100MG | 337 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSBI-115
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NoteResearch use only, not for human use.
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Brief DescriptionSBI-115 is an?antagonist of?TGR5.?SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5.
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DescriptionSBI-115 is an?antagonist of?TGR5.?SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5.
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In VitroSBI-115 (100-200 μM, 24 hours) inhibits proliferation triggered by pre-treatment of cystic cholangiocytes with Taurolithocholic acid (TLCA) in shRNA-transfected ADPKD cholangiocytes. Cell Proliferation Assay Cell Line:shRNA-transfected ADPKD cholangiocytes Concentration:100, 200 μM Incubation Time:24 hours Result:Inhibited proliferation (by 32-48%) triggered by pre-treatment of cystic cholangiocytes with TLCA.
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In Vivo——
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Synonyms——
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PathwayGPCR/G Protein
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TargetGPCR19
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RecptorTGR5
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Research Area——
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Indication——
Chemical Information
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CAS Number882366-16-7
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Formula Weight340.78
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Molecular FormulaC14H13ClN2O4S
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Purity>98% (HPLC)
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SolubilityDMSO:150 mg/mL (440.17 mM)
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SMILESCCS(=O)(=O)c1ncc(Cl)c(C(=O)Oc2cccc(C)c2)n1
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Chemical Name4-Pyrimidinecarboxylic acid 5-chloro-2-(ethylsulfonyl)- 3-methylphenyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Masyuk TV Masyuk AI Lorenzo Pisarello Met al.TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling[J].Hepatology. 2017 Oct;66(4):1197-1218.
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SBI-115 is an?antagonist of?TGR5.?SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5.
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