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Ruzasvir
CAS No. 1613081-64-3
Ruzasvir( MK-8408 | MK 8408 | MK8408 )
Catalog No. M12336 CAS No. 1613081-64-3
A potent, pan-genotype HCV NS5A inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 432 | In Stock |
|
| 10MG | 618 | In Stock |
|
| 25MG | 972 | In Stock |
|
| 50MG | 1332 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRuzasvir
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, pan-genotype HCV NS5A inhibitor.
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DescriptionA potent, pan-genotype HCV NS5A inhibitor with replicon EC90 of 0.003, 0.016, 0.067, 0.036, 0.007, and 0.007 nM for GT1a, GT1a L31V, GT1a Y93H, GT2b, GT3a, and Gt4a, respectively.HCV Infection Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsMK-8408 | MK 8408 | MK8408
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PathwayMicrobiology/Virology
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TargetHCV
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RecptorHCV
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Research AreaInfection
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IndicationHCV Infection
Chemical Information
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CAS Number1613081-64-3
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Formula Weight947.1
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Molecular FormulaC49H55FN10O7S
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Purity>98% (HPLC)
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Solubility——
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SMILESFC1=C(C(N2[C@H](C3=CN=C(C4CC4)S3)O5)=CC6=C2C=CC(C7=CN=C(C8N(C(C(NC(OC)=O)C(C)C)=O)CCC8)N7)=C6)C5=CC(C9=CN=C([C@H]%10N(C(C(NC(OC)=O)C(C)C)=O)CCC%10)N9)=C1
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Chemical NameDimethyl N,N'-([(6S)-6-(2-cyclopropyl-1,3-thiazol-5-yl)-1-fluoro-6H-indolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis{(1H-imidazole-4,2-diyl)[(2S)-pyrrolidine-2,1- diyl][(2S)-3-methyl-1-oxobutane-1,2-diyl]})dicarbamate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tong L, et al. J Med Chem. 2017 Jan 12;60(1):290-306.
2. Wyles D, et al. Hepatology. 2017 Dec;66(6):1794-1804.
3. Lawitz E, et al. Lancet Gastroenterol Hepatol. 2017 Nov;2(11):814-823.
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