MK-8325( MK8325 )

Catalog No. M11331 CAS No. 1334312-52-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MK-8325
Note

Research use only, not for human use.
Brief Description

MK-8325 is a potent, selective pan-genotype HCV NS5A inhibitor with IC50 of 15, 1 and 3 pM for GT1a, GT1b and GT2a, respectively.
Description

MK-8325 is a potent, selective pan-genotype HCV NS5A inhibitor with IC50 of 15, 1 and 3 pM for GT1a, GT1b and GT2a, respectively; also demonstrates potencies comparable to MK-4882 against a panel of mutants in both the GT1a and GT1b backgrounds (GT1a M28V IC50=0.1 nM); demonstrates no cell toxicity with a CC50 >25 uM against Huh-7 replicon cells.HCV Infection Phase 1 Clinical.
In Vitro

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In Vivo

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Synonyms

MK8325
Pathway

Microbiology/Virology
Target

HCV
Recptor

HCV
Research Area

Infection
Indication

HCV Infection

CAS Number

1334312-52-5
Formula Weight

843.021
Molecular Formula

C43H52F2N8O6Si
Purity

>98% (HPLC)
Solubility

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SMILES

CC(C)C(C(=O)N1CC(CC1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC5=C(C=C4)C6=C(C=C5)NC(=N6)C7C[Si](CN7C(=O)C(C(C)C)NC(=O)OC)(C)C)(F)F)NC(=O)OC
Chemical Name

methyl ((S)-1-((R)-5-(7-(4-(2-((S)-4,4-difluoro-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)phenyl)-1H-naphtho[1,2-d]imidazol-2-yl)-3,3-dimethyl-1,3-azasilolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

1. Nair AG, et al. Bioorg Med Chem Lett. 2018 Mar 20. pii: S0960-894X(18)30242-7.

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