RUC-4( RUC4 | RUC 4 )

Catalog No. M11916 CAS No. 1448313-27-6

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HPLC

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Product Name

RUC-4
Note

Research use only, not for human use.
Brief Description

A potent, selective, non-RGD-mimetic αIIbβ3 integrin receptor antagonist with IC50 of 45 nM, with no activity on αVβ3 receptors.
Description

A potent, selective, non-RGD-mimetic αIIbβ3 integrin receptor antagonist with IC50 of 45 nM, with no activity on αVβ3 receptors.
In Vitro

——
In Vivo

Zalunfiban (1~3.86 mg/kg; s.c.; 24 hours) makes platelet aggregationperformed.Zalunfiban (1~3.86 mg/kg; i.m.; 4.5 hours) leads to the onset of high-grade inhibition of platelet aggregation within 15-30 minutes that lasted from ~2 to >4.5 hours in a dose dependent manner. Animal Model:Cynomolgus Monkey Dosage:1~3.86 mg/kg (Pharmacokinetic Analysis) Administration:S.c.; 24 hours Result:Platelet aggregation was performed.
Synonyms

RUC4 | RUC 4
Pathway

Cell Cycle/DNA Damage
Target

Integrin
Recptor

Integrin
Research Area

——
Indication

——

CAS Number

1448313-27-6
Formula Weight

386.434
Molecular Formula

C16H18N8O2S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 17.86 mg/mL (46.22 mM)
SMILES

O=C(NC1=NC=CC(C(S2)=NN(C2=NC(N3CCNCC3)=C4)C4=O)=C1)CN
Chemical Name

2-amino-N-(5-(5-oxo-7-(piperazin-1-yl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)pyridin-3-yl)acetamide

1. Miller LM, et al. J Med Chem. 2017 Apr 27;60(8):3241-3251. 2. Jiang JK, et al. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1148-53.

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