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RSS0680

CAS No. 2769753-48-0

RSS0680( —— )

Catalog No. M36605 CAS No. 2769753-48-0

RSS0680 is a protein kinase degrader that degrades a variety of kinases and can be used to study diseases caused by kinase abnormalities.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    RSS0680
  • Note
    Research use only, not for human use.
  • Brief Description
    RSS0680 is a protein kinase degrader that degrades a variety of kinases and can be used to study diseases caused by kinase abnormalities.
  • Description
    RSS0680 (Example 22) is a bifunctional compound targeted protein degradation of kinases. RSS0680 degrades AAK1, CDK1, CDK16, CDK2, CDK4, CDK6, EIF2AK4, GAK, LATSl, LIMK2, MAPK6, MAPKAPK5, MARK2, MARK4, MKNK2, NEK9, RPS6KB1, SIK2, SNRK, STK17A, STK17B, STK35, and WEEl. RSS0680 can be used for research of disease or disorder mediated by aberrant kinase activity.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PROTACs | AMPK | CDK | AAK1 (AP2 associated kinase 1)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2769753-48-0
  • Formula Weight
    1021.32
  • Molecular Formula
    C52H64N10O6S3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 200 mg/mL (195.83 mM; Ultrasonic (<60°C)
  • SMILES
    N(C=1N=C2C(=CSC2=CN1)C3=CC(NS(C)(=O)=O)=CC=C3)C4=CC=C(C=C4)N5CCN(CCCCCC(N[C@H](C(=O)N6[C@H](C(N[C@@H](C)C7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6)[C@@](C)(C)C)=O)CC5
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gray Nathanael S, et al. Bifunctional compounds for targeted protein degradation of kinases: World Intellectual Property Organization, WO2022093742[P]. 2022-05-05.
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