RSS0680

Research use only, not for human use.

RSS0680 is a protein kinase degrader that degrades a variety of kinases and can be used to study diseases caused by kinase abnormalities.

RSS0680 (Example 22) is a bifunctional compound targeted protein degradation of kinases. RSS0680 degrades AAK1, CDK1, CDK16, CDK2, CDK4, CDK6, EIF2AK4, GAK, LATSl, LIMK2, MAPK6, MAPKAPK5, MARK2, MARK4, MKNK2, NEK9, RPS6KB1, SIK2, SNRK, STK17A, STK17B, STK35, and WEEl. RSS0680 can be used for research of disease or disorder mediated by aberrant kinase activity.

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Others

Other Targets

PROTACs | AMPK | CDK | AAK1 (AP2 associated kinase 1)

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2769753-48-0

1021.32

C52H64N10O6S3

>98% (HPLC)

In Vitro:?DMSO : 200 mg/mL (195.83 mM; Ultrasonic (<60°C)

N(C=1N=C2C(=CSC2=CN1)C3=CC(NS(C)(=O)=O)=CC=C3)C4=CC=C(C=C4)N5CCN(CCCCCC(N[C@H](C(=O)N6[C@H](C(N[C@@H](C)C7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6)[C@@](C)(C)C)=O)CC5

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(-20℃)

With Ice Pack

≥ 2 years