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Pyributicarb
CAS No. 88678-67-5
Pyributicarb( TSH-888 )
Catalog No. M20997 CAS No. 88678-67-5
Pyributicarb is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR).?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 43 | Get Quote |
|
| 50MG | 65 | Get Quote |
|
| 100MG | 95 | Get Quote |
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| 200MG | 140 | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePyributicarb
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NoteResearch use only, not for human use.
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Brief DescriptionPyributicarb is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR).?
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DescriptionPyributicarb is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR).?
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In VitroPyributicarb, a carbamate-type herbicide, is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR). Pyributicarb is found to increase the CYP3A4 reporter activity at 0.1 to 1 μM more strongly than typical CYP3A4 inducer rifampicin. Expression of hPXR-siRNA clearly diminishes the Pyributicarb-stimulated CYP3A4 reporter activity in 3-1-10 cells and decreases the endogenous CYP3A4 mRNA levels in HepG2 cells. Pyributicarb induces luciferase transcription via hPXR at low concentrations in the order of 10 nM. The relative potency of Pyributicarb for hPXR is 8.6-fold that of rifampicin (RIF).
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In VivoPyributicarb causes enhancement of CYP3A4-derived reporter activity in mouse livers introduced with hPXR by adenovirus.
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SynonymsTSH-888
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PathwayMetabolic Enzyme/Protease
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TargetP450
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RecptorCYP3A4
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Research Area——
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Indication——
Chemical Information
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CAS Number88678-67-5
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Formula Weight330.44
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Molecular FormulaC18H22N2O2S
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (302.63 mM)
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SMILESCOc1cccc(N(C)C(=S)Oc2cccc(C(C)(C)C)c2)n1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Matsubara T Noracharttiyapot W Toriyabe T et al. Assessment of Human Pregnane X Receptor Involvement in Pesticide-Mediated Activation of CYP3A4 Gene[J]. Drug Metabolism and Disposition 2007 35(5):728-733.
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