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Home - Products - Metabolic Enzyme/Protease - PPAR - Pemafibrate

Pemafibrate

CAS No. 848259-27-8

Pemafibrate( K-877 )

Catalog No. M16159 CAS No. 848259-27-8

A highly potent, specific PPARα agonist with EC50 of 1 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Pemafibrate
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly potent, specific PPARα agonist with EC50 of 1 nM.
  • Description
    A highly potent, specific PPARα agonist with EC50 of 1 nM; displays >2,000-fold selectivity for PPARα over others subtypes in a CHO cell-based transactivation assay; upregulates the expression of several fatty acid β-oxidative genes in human hepatocytes and the mouse liver; significantly induces the expression of clinically beneficial target genes (VLDLR, FGF21, ABCA1, MBL2, ENPEP) in human hepatocytes.Dyslipidemia Approved.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    K-877
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    PPAR
  • Recptor
    PPAR
  • Research Area
    Cardiovascular Disease
  • Indication
    Dyslipidemia

Chemical Information

  • CAS Number
    848259-27-8
  • Formula Weight
    490.5476
  • Molecular Formula
    C28H30N2O6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO
  • SMILES
    CC[C@@H](OC1=CC=CC(CN(C2=NC3=CC=CC=C3O2)CCCOC4=CC=C(OC)C=C4)=C1)C(O)=O
  • Chemical Name
    Butanoic acid, 2-[3-[[2-benzoxazolyl[3-(4-methoxyphenoxy)propyl]amino]methyl]phenoxy]-, (2R)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ishibashi S, et al. Atherosclerosis. 2016 Jun;249:36-43. 2. Yamazaki Y, et al. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4689-93. 3. Raza-Iqbal S, et al. J Atheroscler Thromb. 2015 Aug 26;22(8):754-72.
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