PRMT6-IN-3

CAS No. 2890765-10-1

PRMT6-IN-3( —— )

Catalog No. M36506 CAS No. 2890765-10-1

PRMT6-IN-3 is a selective PRMT6 inhibitor with an IC50 value of 192 nM.PRMT6-IN-3 has anticancer activity and induces apoptosis in cancer cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 73 Get Quote
5MG 107 Get Quote
10MG 163 Get Quote
25MG 273 Get Quote
50MG 419 Get Quote
100MG 573 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    PRMT6-IN-3
  • Note
    Research use only, not for human use.
  • Brief Description
    PRMT6-IN-3 is a selective PRMT6 inhibitor with an IC50 value of 192 nM.PRMT6-IN-3 has anticancer activity and induces apoptosis in cancer cells.
  • Description
    PRMT6-IN-3 (compound 25) is a selective PRMT6 inhibitor with an IC50 value of 192 nM. PRMT6-IN-3 can induce apoptosis in cancer cells and has anticancer activity.
  • In Vitro
    PRMT6-IN-3(compound 25) (80 μM, 3-7 days) has anti-proliferative activity against HCC827 and MDA-MB-435 cells. PRMT6-IN-3(compound 25) (0-40 μM, 72 h) significantly induces apoptosis of cancer cells in a dose-dependent manner. Among them, a concentration of 40 μM could induce apoptosis in 43.44% and 35.08% of HCC827 and MDA-MB-435 cells, respectively.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Histone Methyltransferase | Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2890765-10-1
  • Formula Weight
    374.5
  • Molecular Formula
    C19H26N4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(N(CCNC)C)C1=CC(=CN=C1)C2=CC=C(NS(=O)(=O)C3CC3)C=C2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Qiangsheng Zhang, et al. Design, synthesis and evaluation of antitumor activity of selective PRMT6 inhibitors. Eur J Med Chem. 2022 Dec 20;247:115032.?
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