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PIK-108

CAS No. 901398-68-3

PIK-108( PIK 108 | PIK108 )

Catalog No. M24934 CAS No. 901398-68-3

PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PIK-108
  • Note
    Research use only, not for human use.
  • Brief Description
    PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).
  • Description
    PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).
  • In Vitro
    PIK-108 (0.1-10 μM; 1 hour) blocks phosphorylation of PKB/Akt.Western Blot Analysis Cell Line:Glioma cell lines expressing wild-type PTEN Concentration:0.1, 0.5, 1, 4, and 10 μM Incubation Time:1 hour Result:Showed variable inhibition of PKB/Akt phosphorylation but exhibited a trend toward reducing PKB/Akt phosphorylation more effectively in mutant PTEN-expressing cell lines than in wild-type PTEN-expressing cell lines.
  • In Vivo
    ——
  • Synonyms
    PIK 108 | PIK108
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PI3K
  • Recptor
    PI3Kα|PI3Kβ
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    901398-68-3
  • Formula Weight
    364.44
  • Molecular Formula
    C22H24N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:45 mg/mL?(123.48 mM;?Need ultrasonic)
  • SMILES
    O=C1C=C(N2CCOCC2)OC3=C(C(NC4=CC=CC=C4)C)C=C(C)C=C13
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Certal V, Halley F, Virone-Oddos A, Delorme C, Karlsson A, Rak A, Thompson F, Filoche-Rommé B, El-Ahmad Y, Carry JC et al.. (2012) Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective PI3Kβ inhibitors for the treatment of phosphatase and TENsin homologue (PTEN)-deficient cancers. J. Med. Chem., 55 (10): 4788-805. [PMID:22524426]
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