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PQR-530
CAS No. 1927857-61-1
PQR-530( PQR530 )
Catalog No. M13022 CAS No. 1927857-61-1
PQR-530 (PQR530) is a potent, BBB penetrant, dual pan-PI3K/mTOR inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 71 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 93 | In Stock |
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| 25MG | 187 | In Stock |
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| 50MG | 272 | In Stock |
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| 100MG | 398 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePQR-530
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NoteResearch use only, not for human use.
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Brief DescriptionPQR-530 (PQR530) is a potent, BBB penetrant, dual pan-PI3K/mTOR inhibitor.
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DescriptionPQR-530 (PQR530) is a potent, BBB penetrant, dual pan-PI3K/mTOR inhibitor with Kd of 0.3/1/6/11/10 nM for mTOR/PIK3CA/PIK3CB/PIK3CD/PIK3CG, respectively; effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy.
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In VitroPQR-530 is a potent, oral and brain-penetrant dual pan-PI3K/mTORC1/2 inhibitor, exhibiting antitumor activity. PQR-530 inhibits all PI3K isoforms and mTOR complexes C1/2 potently and selectively. PQR-530 inhibits protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phosphorylation with IC50 values of 0.07 μM in A2058 melanoma cells. PQR-530 shows inhibitory activity against the growth of 44 cancer cell lines with mean GI50 of 426 nM.
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In Vivo——
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SynonymsPQR530
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3K
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1927857-61-1
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Formula Weight407.42
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Molecular FormulaC18H23F2N7O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 33.33 mg/mL (81.81 mM)
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SMILESNC1=NC=C(C2=NC(N3[C@@H](C)COCC3)=NC(N4CCOCC4)=N2)C(C(F)F)=C1
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Chemical Name(S)-4-(difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Brandt C, et al. Neuropharmacology. 2018 Aug 3;140:107-120.
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