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PF-956980
CAS No. 1262832-74-5
PF-956980( PF 956980 | PF956980 )
Catalog No. M11099 CAS No. 1262832-74-5
A potent, highly specific JAK3 inhibitor with IC50 of 4 nM; shows only modest inhibition of PKA (6.7 uM) and LCK (10.9 uM) in vitro.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePF-956980
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, highly specific JAK3 inhibitor with IC50 of 4 nM; shows only modest inhibition of PKA (6.7 uM) and LCK (10.9 uM) in vitro.
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DescriptionA potent, highly specific JAK3 inhibitor with IC50 of 4 nM; shows only modest inhibition of PKA (6.7 uM) and LCK (10.9 uM) in vitro; selectively downregulates JAK2 and JAK3 mRNA, corresponding to changes observed at the protein level; shows in vivo activity consistent with in vitro enzyme and whole blood assays (39 ng/ml); dose-dependently inhibits the DTH response in mice with EC50 of 5 mg/kg.
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In Vitro——
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In Vivo——
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SynonymsPF 956980 | PF956980
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PathwayAngiogenesis
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TargetJAK
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RecptorJAK
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number1262832-74-5
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Formula Weight342.44
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Molecular FormulaC18H26N6O
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(N1C[C@H](N(C)C2=C3C(NC=C3)=NC=N2)[C@H](C)CC1)N4CCCC4
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Chemical Name{(3R,4R)-4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-pyrrolidin-1-yl-methanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Changelian PS, et al. Blood. 2008 Feb 15;111(4):2155-7.
2. Steele AJ, et al. Blood. 2010 Nov 25;116(22):4569-77.
3. Field SD, et al. ACS Chem Biol. 2017 May 19;12(5):1183-1187.
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