PF-06700841 tosylate( PF-6700841 | PF-841 )

Catalog No. M13422 CAS No. 2140301-96-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PF-06700841 tosylate
Note

Research use only, not for human use.
Brief Description

PF-06700841 is a potent, selective TYK2/JAK1 kinase inhibitor that reduces IL-23 expression and directly attenuates IL-23 signaling via TYK2.
Description

PF-06700841 is a potent, selective TYK2/JAK1 kinase inhibitor that reduces IL-23 expression and directly attenuates IL-23 signaling via TYK2; is under investigation for the treatment of plaque psoriasis and lupus erythematosus.Psoriasis Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

PF-6700841 | PF-841
Pathway

Angiogenesis
Target

JAK
Recptor

JAK
Research Area

——
Indication

——

CAS Number

2140301-96-6
Formula Weight

561.609
Molecular Formula

C25H29F2N7O4S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C([C@H]1C(F)(F)C1)N2C3CN(C4=NC(NC5=CN(C)N=C5)=NC=C4)CC2CC3.OS(=O)(C6=CC=C(C)C=C6)=O
Chemical Name

((S)-2,2-difluorocyclopropyl)(3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone 4-methylbenzenesulfonate

1. Banfield C, et al. J Clin Pharmacol. 2017 Dec 21. doi: 10.1002/jcph.1046.

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