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PF-04958242
CAS No. 1258963-59-5
PF-04958242( PF04958242 )
Catalog No. M11068 CAS No. 1258963-59-5
PF-04958242 is a novel potent, selctive, and orally-active AMPA receptor (AMPAR) positive allosteric modulator (PAM) with Ki of 170 nM, EC50 of 370 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 314 | In Stock |
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| 25MG | 665 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePF-04958242
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NoteResearch use only, not for human use.
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Brief DescriptionPF-04958242 is a novel potent, selctive, and orally-active AMPA receptor (AMPAR) positive allosteric modulator (PAM) with Ki of 170 nM, EC50 of 370 nM.
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DescriptionPF-04958242 is a novel potent, selctive, and orally-active AMPA receptor (AMPAR) positive allosteric modulator (PAM) with Ki of 170 nM, EC50 of 370 nM; is under development for the treatment of cognitive symptoms in schizophrenia.Schizophrenia Phase 1 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsPF04958242
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PathwayMembrane Transporter/Ion Channel
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TargetiGluR
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RecptoriGluR
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Research AreaNeurological Disease
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IndicationSchizophrenia
Chemical Information
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CAS Number1258963-59-5
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Formula Weight392.49
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Molecular FormulaC18H20N2O4S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (254.78 mM)
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SMILESCC(C)S(=O)(=O)NC1COCC1OC2=CC=C(C=C2)C3=CC=C(S3)C#N
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Chemical NameN-((3S,4S)-4-(4-(5-cyano-2-thienyl)phenoxy)tetrahydro-3-furanyl)-2-propanesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shaffer CL, et al. J Med Chem. 2015 May 28;58(10):4291-308.
2. Ranganathan M, et al. Mol Psychiatry. 2017 Feb 28. doi: 10.1038/mp.2017.6.
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