JNJ-61432059( —— )

Catalog No. M26724 CAS No. 2035814-50-5

JNJ-61432059 is an oral active and selective negative modulator of TARP γ 8 Selective AMPAR(pIC50: 9.7).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

JNJ-61432059
Note

Research use only, not for human use.
Brief Description

JNJ-61432059 is an oral active and selective negative modulator of TARP γ 8 Selective AMPAR(pIC50: 9.7).
Description

JNJ-61432059 is an oral active and selective negative modulator of TARP γ 8 Selective AMPAR(pIC50: 9.7).(In Vivo):In mouse hippocampus, Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Membrane Transporter/Ion Channel
Target

iGluR
Recptor

SHMT1| SHMT2
Research Area

——
Indication

——

Chemical Information

CAS Number

2035814-50-5
Formula Weight

443.482
Molecular Formula

C25H22FN5O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (112.75 mM)
SMILES

OC1CCN(CC1)c1nccc2c(c(nn12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Ducker GS, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409.

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