JNJ-61432059( —— )

Catalog No. M26724 CAS No. 2035814-50-5

JNJ-61432059 is an oral active and selective negative modulator of TARP γ 8 Selective AMPAR(pIC50: 9.7).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	258	In Stock
5MG	235	In Stock
10MG	335	In Stock
25MG	561	In Stock
50MG	732	In Stock
100MG	977	In Stock
200MG	1321	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

JNJ-61432059
Note

Research use only, not for human use.
Brief Description

JNJ-61432059 is an oral active and selective negative modulator of TARP γ 8 Selective AMPAR(pIC50: 9.7).
Description

JNJ-61432059 is an oral active and selective negative modulator of TARP γ 8 Selective AMPAR(pIC50: 9.7).(In Vivo):In mouse hippocampus, Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Membrane Transporter/Ion Channel
Target

iGluR
Recptor

SHMT1| SHMT2
Research Area

——
Indication

——

Chemical Information

CAS Number

2035814-50-5
Formula Weight

443.482
Molecular Formula

C25H22FN5O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (112.75 mM)
SMILES

OC1CCN(CC1)c1nccc2c(c(nn12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Ducker GS, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409.

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