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PF-04745637
CAS No. 1917294-46-2
PF-04745637( —— )
Catalog No. M26002 CAS No. 1917294-46-2
PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 222 | In Stock |
|
| 10MG | 311 | In Stock |
|
| 25MG | 525 | In Stock |
|
| 50MG | 750 | In Stock |
|
| 100MG | 1035 | In Stock |
|
| 500MG | 2061 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePF-04745637
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NoteResearch use only, not for human use.
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Brief DescriptionPF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM.
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DescriptionPF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM.(In Vivo):PF-04745637 (topically applied; 50 mg/mL and 100 mg/mL) significantly reduces cinnamaldehyde-mediated flare in rat skin.
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In Vitro——
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In VivoTopically applied PF-04745637 (Compound 8; 50 mg/mL and 100 mg/mL) significantly reduces cinnamaldehyde-mediated flare in rat skin.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorImmunology/Inflammation related
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Research Area——
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Indication——
Chemical Information
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CAS Number1917294-46-2
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Formula Weight509.01
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Molecular FormulaC27H32ClF3N2O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (245.58 mM)
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SMILESOC1(CCN(CC1)C(CNC(=O)C1(CCCC1)c1ccc(Cl)cc1)Cc1ccccc1)C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Constituents of Compositae plants III. Anti-tumor promoting effects and cytotoxic activity against human cancer cell lines of triterpene diols and triols from edible chrysanthemum flowers.Cancer Lett., 2002, 177(1):7-12.
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