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RQ00203078

CAS No. 1254205-52-1

RQ00203078( RQ-00203078 | RQ 00203078 | RQ00203078 )

Catalog No. M11029 CAS No. 1254205-52-1

RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    RQ00203078
  • Note
    Research use only, not for human use.
  • Brief Description
    RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively).
  • Description
    RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively), exhibits >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    RQ-00203078 | RQ 00203078 | RQ00203078
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRPM8
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1254205-52-1
  • Formula Weight
    554.85
  • Molecular Formula
    C21H13ClF6N2O5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 100 mM
  • SMILES
    O=C(O)C1=CC=C(S(=O)(N(C2=NC=C(C(F)(F)F)C=C2Cl)CC3=CC=C(OC(F)(F)F)C=C3)=O)C=C1
  • Chemical Name
    4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chaussade C, et al. Biochem J, 2007, 404(3), 449-58.
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