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Home - Products - GPCR/G Protein - Histamine Receptor - PF-03654746

PF-03654746

CAS No. 935840-31-6

PF-03654746( PF 3654746 )

Catalog No. M16694 CAS No. 935840-31-6

PF-03654746 (PF 3654746) is a potent, selective, orally bioactive antagonist of H3 receptor with Ki of 2.3 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PF-03654746
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-03654746 (PF 3654746) is a potent, selective, orally bioactive antagonist of H3 receptor with Ki of 2.3 nM.
  • Description
    PF-03654746 (PF 3654746) is a potent, selective, orally bioactive antagonist of H3 receptor with Ki of 2.3 nM; dislaplays >1000-fold selectivity versus H1, H2, H4 and other GPCRs (IC50>10 uM); possesses optimal pharmacological and pharmacokinetic profiles, shows potential in allergen-induced nasal symptoms.Allergy Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PF 3654746
  • Pathway
    GPCR/G Protein
  • Target
    Histamine Receptor
  • Recptor
    Histamine Receptor
  • Research Area
    Inflammation/Immunology
  • Indication
    Allergy

Chemical Information

  • CAS Number
    935840-31-6
  • Formula Weight
    322.4
  • Molecular Formula
    C18H24F2N2O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C([C@H]1C[C@@](C2=CC=C(CN3CCCC3)C(F)=C2)(F)C1)NCC
  • Chemical Name
    Trans-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wager TT, et al. J Med Chem. 2011 Nov 10;54(21):7602-20. 2. Stokes JR, et al. J Allergy Clin Immunol. 2012 Feb;129(2):409-12, 412.e1-2. 3. Gallezot JD, et al. J Cereb Blood Flow Metab. 2017 Mar;37(3):1095-1107.
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