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PAP-1

CAS No. 870653-45-5

PAP-1( 5-(4-Phenoxybutoxy)psoralen )

Catalog No. M24882 CAS No. 870653-45-5

PAP-1 is a selective, and orally active Kv1.3 blocker (EC50: 2 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PAP-1
  • Note
    Research use only, not for human use.
  • Brief Description
    PAP-1 is a selective, and orally active Kv1.3 blocker (EC50: 2 nM).
  • Description
    PAP-1 is a selective, and orally active Kv1.3 blocker (EC50: 2 nM).
  • In Vitro
    PAP-1 (2-100 nM; 30 minutes) suppresses the proliferation of CCR7-TEM cells with IC50 of 10 nM. Cell Proliferation Assay Cell Line:CCR7-TEM cells (anti-CD3 Ab stimulated)Concentration:2, 10, 25, 100 nM Incubation Time:30 minutes Result:Suppresses the Proliferation of CCR7-TEM cells with IC50 of 10 nM.
  • In Vivo
    PAP-1 (0.3-3 mg/kg; i.p.; three times daily for 48 hours) prevents delayed type hypersensitivity (DTH) in lewis rats. Animal Model:9- to 11- week-old female Lewis rats Dosage:Intraperitoneal injection; three times daily for 48 hours Administration:0.3, 1, 3 mg/kg Result:Dose-dependently suppressed the DTH reaction.
  • Synonyms
    5-(4-Phenoxybutoxy)psoralen
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Kv1.3 channels
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    870653-45-5
  • Formula Weight
    350.36
  • Molecular Formula
    C21H18O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:48 mg/mL (137 mM; Need ultrasonic);Water:Insoluble
  • SMILES
    O=C(C=C1)Oc2c1c(OCCCCOc1ccccc1)c(cco1)c1c2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Schmitz A, et al. Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases. Mol Pharmacol. 2005 Nov;68(5):1254-70.
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