Oxybutynin

Research use only, not for human use.

Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.

Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.(In Vitro):Oxybutynin (0.1, 0.3, 1, 3, 10, 30, 100 μM; 200 ms) inhibits vascular Kv channels in a concentration-dependent manner independent of anticholinergic effect in coronary arterial smooth muscle cells.(In Vivo):Oxybutynin (27.2 mg/kg; p.o.; single) exhibits significant binding of mouse brain muscarinic receptors that about a 2-fold increase in Kd?values for specific [3H]N-methylscopolamine binding 0.5 and 2 h later.

Oxybutynin (0.1, 0.3, 1, 3, 10, 30, 100 μM; 200 ms) inhibits vascular Kv channels in a concentration-dependent manner independent of anticholinergic effect in coronary arterial smooth muscle cells. Cell Viability Assay Cell Line:Coronary arterial smooth muscle cells (from male New Zealand White rabbits)Concentration:10 μM Incubation Time:200 ms Result:Rapidly inhibited the Kv current within 2 min and reduced the Kv current by 44% at +60 Mv.Inhibited the Kv current by changing the gating properties of Kv channels.Cell Viability Assay Cell Line:Coronary arterial smooth muscle cells (from male New Zealand White rabbits) Concentration:0.1, 0.3, 1, 3, 10, 30, 100 μM Incubation Time:200 ms Result:Reduced the Kv current amplitude in a concentration-dependent manner, with an IC50 value of 11.51 μM.

Oxybutynin (27.2 mg/kg; p.o.; single) exhibits significant binding of mouse brain muscarinic receptors that about a 2-fold increase in Kd values for specific [3H]N-methylscopolamine binding 0.5 and 2 h later. Animal Model:Male ddY strain mice (9 to 13-week-old).Dosage:27.2 mg/kg (76.1 μmol/kg) Administration:Oral administration; single.Result:Significant increased Kd values for specific [3H]NMS binding in mouse bladder with values of 54.7% and 40.6% when at 0.5 and 2 hours, respectively.Significant increased Kd values for specific [3H]NMS binding in mouse cerebral cortex with values of 120% and 71.2% when at 0.5 and 2 hours, respectively.

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Endocrinology/Hormones

AChR

mAChR

Neurological Disease

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5633-20-5

357.49

C22H31NO3

>98% (HPLC)

Ethanol: 71 mg/mL (198.6 mM); DMSO: 71 mg/mL (198.6 mM)

CCN(CC)CC#CCOC(=O)C(O)(C1CCCCC1)C1=CC=CC=C1

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(-20℃)

With Ice Pack

≥ 2 years