Narasin (sodium salt)( HainanMycin | naransin sodium | Naracin sodium salt )

Catalog No. M27432 CAS No. 58331-17-2

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HNMR

HPLC

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Product Name

Narasin (sodium salt)
Note

Research use only, not for human use.
Brief Description

Narasin induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis by ER stress in glioma cells and inhibits NF-κB signaling by suppressing the phosphorylation of IκBα.
Description

Narasin induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis by ER stress in glioma cells and inhibits NF-κB signaling by suppressing the phosphorylation of IκBα.(In Vitro):Narasin caused suicidal erythrocyte death or eryptosis. In human erythrocytes, Narasin increased annexin-V-binding indicating cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface and the decrease of forward scatter reflecting cell shrinkage, which indicated the death of erythrocyte. (In Vivo):Administration of 4-48 p.p.m of narasin in the pelleted feed of New Zealand White rabbits. After 4 weeks, narasin protected rabbits from severe coccidiosis induced by E. flavescens, E. perforans E. Magna, E. Intestinalis, and E. Stiedai. In addition, narasin reduced oocyst output effectively.
In Vitro

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In Vivo

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Synonyms

HainanMycin | naransin sodium | Naracin sodium salt
Pathway

Apoptosis
Target

NF-κB
Recptor

——
Research Area

——
Indication

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CAS Number

58331-17-2
Formula Weight

787.01
Molecular Formula

C43H71NaO11
Purity

>98% (HPLC)
Solubility

——
SMILES

CC[C@@H](C([O-])=O)[C@H]1[C@@H](C)C[C@H](C)[C@H]([C@H]([C@H](O)[C@@H](C([C@@H]([C@@H]2[C@@H](C)C[C@@H](C)[C@@]3(C=C[C@@H](O)[C@]4(CC[C@@](C)([C@H]5CC[C@@](CC)(O)C(C)O5)O4)O3)O2)CC)=O)C)C)O1.[Na+]
Chemical Name

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1.Da-Wa ZM, et al. Chemical Constituents from Przewalskia tangutica. Zhong Yao Cai. 2016 Sep;39(9):2013-5.

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