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CHPG sodium salt
CAS No. 1303993-73-8
CHPG sodium salt( —— )
Catalog No. M32846 CAS No. 1303993-73-8
CHPG sodium salt is a selective agonist of mGluR5 that activates ERK and Akt signaling pathways and is utilized in studies on traumatic brain injury.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 38 | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameCHPG sodium salt
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NoteResearch use only, not for human use.
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Brief DescriptionCHPG sodium salt is a selective agonist of mGluR5 that activates ERK and Akt signaling pathways and is utilized in studies on traumatic brain injury.
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DescriptionCHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways..
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In VitroCell Viability Assay Cell Line:BV2 microglial cells Concentration:10, 50, 100 and 500?μM Incubation Time:24?hours Result:Increased the cell viability. Apoptosis Analysis Cell Line:BV2 microglial cells Concentration:0.5?mM Incubation Time:30?mins Result:Protected BV2 cells against SO2-induced apoptosis.Western Blot Analysis Cell Line:BV2 microglial cells Concentration:0.5?mM Incubation Time:30?mins Result:Increased the expression of TSG-6 in both mRNA and protein levels.
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In VivoAnimal Model:Adult Sprague-Dawley male rats weighing 280-320 g Dosage:250 nM Administration:Injection; for 7 days Result:Reduced significantly cerebral lesion volume.
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Synonyms——
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PathwayApoptosis
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TargetNF-κB
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RecptorNF-κB | GluR
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Research Area——
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Indication——
Chemical Information
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CAS Number1303993-73-8
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Formula Weight223.59
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Molecular FormulaC8H7ClNNaO3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (447.25 mM; Ultrasonic ) H2O : 6.67 mg/mL (29.83 mM; Ultrasonic (<80°C)
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SMILESC1=CC(=C(C=C1O)C(C(=O)[O-])N)Cl.[Na+]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Qiu JL, et al. The selective mGluR5 agonist CHPG attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. Neurochem Int. 2015 Jun-Jul;85-86:46-52.?
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