Cart
sales@molnova.com
IT-603
CAS No. 292168-90-2
IT-603( IT 603 | IT603 )
Catalog No. M13900 CAS No. 292168-90-2
A small molecule inhibitor of the NF-κB family member c-Rel with IC50 of 3 uM in EMSA assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 136 | In Stock |
|
| 5MG | 122 | In Stock |
|
| 10MG | 202 | In Stock |
|
| 25MG | 376 | In Stock |
|
| 50MG | 584 | In Stock |
|
| 100MG | 828 | In Stock |
|
| 200MG | 1135 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameIT-603
-
NoteResearch use only, not for human use.
-
Brief DescriptionA small molecule inhibitor of the NF-κB family member c-Rel with IC50 of 3 uM in EMSA assays.
-
DescriptionA small molecule inhibitor of the NF-κB family member c-Rel with IC50 of 3 uM in EMSA assays; inhibits human diffuse large B-cell lymphoma (DLBCL) cell line with IC50 of 18 uM, binds c-Rel directly and changes the conformation of the protein, inhibiting DNA binding and transcriptional activity.
-
In Vitro——
-
In Vivo——
-
SynonymsIT 603 | IT603
-
PathwayApoptosis
-
TargetNF-κB
-
RecptorNF-κB
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number292168-90-2
-
Formula Weight329.168
-
Molecular FormulaC11H9BrN2O3S
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 125 mg/mL (379.74 mM)
-
SMILES——
-
Chemical Name5-(5-bromo-2-hydroxy-3-methoxybenzylidene)-2-thioxoimidazolidin-4-one
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Shono Y, et al. Cancer Discov. 2014 May;4(5):578-91.
molnova catalog
related products
-
CID-2858522
CID-2858522 is an effective and specific antigen receptor-mediated NF-κB activation inhibitor (IC50: 70 nM).
-
Iguratimod
A novel disease-modifying antirheumatic drug that inhibits NF-kappaB (NF-κB) p65 subunit (RelA) phosphorylation and nuclear translocation without affecting IKBα degradation.
-
Tyloxapol
Tyloxapol is a non-ionic detergent often used as a surfactant.
