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IT-603
CAS No. 292168-90-2
IT-603( IT 603 | IT603 )
Catalog No. M13900 CAS No. 292168-90-2
A small molecule inhibitor of the NF-κB family member c-Rel with IC50 of 3 uM in EMSA assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 115 | Get Quote |
|
| 10MG | 192 | Get Quote |
|
| 25MG | 385 | Get Quote |
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| 50MG | 575 | Get Quote |
|
| 100MG | 801 | Get Quote |
|
| 500MG | 1647 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameIT-603
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NoteResearch use only, not for human use.
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Brief DescriptionA small molecule inhibitor of the NF-κB family member c-Rel with IC50 of 3 uM in EMSA assays.
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DescriptionA small molecule inhibitor of the NF-κB family member c-Rel with IC50 of 3 uM in EMSA assays; inhibits human diffuse large B-cell lymphoma (DLBCL) cell line with IC50 of 18 uM, binds c-Rel directly and changes the conformation of the protein, inhibiting DNA binding and transcriptional activity.
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In Vitro——
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In Vivo——
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SynonymsIT 603 | IT603
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PathwayApoptosis
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TargetNF-κB
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RecptorNF-κB
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Research Area——
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Indication——
Chemical Information
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CAS Number292168-90-2
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Formula Weight329.168
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Molecular FormulaC11H9BrN2O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (379.74 mM)
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SMILES——
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Chemical Name5-(5-bromo-2-hydroxy-3-methoxybenzylidene)-2-thioxoimidazolidin-4-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shono Y, et al. Cancer Discov. 2014 May;4(5):578-91.
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