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Home - Products - Apoptosis - NF-κB - IT-603

IT-603

CAS No. 292168-90-2

IT-603( IT 603 | IT603 )

Catalog No. M13900 CAS No. 292168-90-2

A small molecule inhibitor of the NF-κB family member c-Rel with IC50 of 3 uM in EMSA assays.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 136 In Stock
5MG 122 In Stock
10MG 202 In Stock
25MG 376 In Stock
50MG 584 In Stock
100MG 828 In Stock
200MG 1135 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    IT-603
  • Note
    Research use only, not for human use.
  • Brief Description
    A small molecule inhibitor of the NF-κB family member c-Rel with IC50 of 3 uM in EMSA assays.
  • Description
    A small molecule inhibitor of the NF-κB family member c-Rel with IC50 of 3 uM in EMSA assays; inhibits human diffuse large B-cell lymphoma (DLBCL) cell line with IC50 of 18 uM, binds c-Rel directly and changes the conformation of the protein, inhibiting DNA binding and transcriptional activity.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    IT 603 | IT603
  • Pathway
    Apoptosis
  • Target
    NF-κB
  • Recptor
    NF-κB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    292168-90-2
  • Formula Weight
    329.168
  • Molecular Formula
    C11H9BrN2O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (379.74 mM)
  • SMILES
    ——
  • Chemical Name
    5-(5-bromo-2-hydroxy-3-methoxybenzylidene)-2-thioxoimidazolidin-4-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shono Y, et al. Cancer Discov. 2014 May;4(5):578-91.
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