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NT157
CAS No. 1384426-12-3
NT157( —— )
Catalog No. M28368 CAS No. 1384426-12-3
NT157 is a small molecule tyrphostin targeting IRS protein and has the potential to inhibit IGF-1R and STAT3 signaling pathways in TME cancer cells and stromal cells, resulting in decreased cancer cell survival.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 100 | Get Quote |
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| 5MG | 178 | Get Quote |
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| 10MG | 268 | Get Quote |
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| 25MG | 484 | Get Quote |
|
| 50MG | 699 | Get Quote |
|
| 100MG | 981 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameNT157
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NoteResearch use only, not for human use.
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Brief DescriptionNT157 is a small molecule tyrphostin targeting IRS protein and has the potential to inhibit IGF-1R and STAT3 signaling pathways in TME cancer cells and stromal cells, resulting in decreased cancer cell survival.
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DescriptionNT157 is a small molecule tyrphostin targeting IRS protein and has the potential to inhibit IGF-1R and STAT3 signaling pathways in TME cancer cells and stromal cells, resulting in decreased cancer cell survival.(In Vitro):NT157 treatment resulted in dose-dependent inhibition of IGF1R activation, suppression of IRS protein expression, inhibition of IGF1-induced AKT activation, but increased ERK activation in NT157-treated cells in vitro.(In Vivo):NT157 suppressed androgen-responsive growth, delayed CRPC progression of LNCaP xenografts, and suppressed PC3 tumor growth alone and in combination with docetaxel.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetIGF-1R
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Recptorgp120/CD4|HIV|PKC
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Research Area——
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Indication——
Chemical Information
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CAS Number1384426-12-3
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Formula Weight412.25
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Molecular FormulaC16H14BrNO5S
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Purity>98% (HPLC)
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Solubility——
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SMILESOc1cc(CNC(=S)\C=C\c2cc(O)c(O)c(Br)c2)cc(O)c1O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ghoul A, et al. Epithelial-to-mesenchymal transition and resistance to ingenol 3-angelate, a novel protein kinase C modulator, in colon cancer cells. Cancer Res. 2009 May 15;69(10):4260-9.
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