KW-2450 free base( —— )

Catalog No. M36254 CAS No. 904899-25-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

KW-2450 free base
Note

Research use only, not for human use.
Brief Description

KW-2450 free base is an orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity.
Description

KW-2450 free base is an orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1R/IR inhibitor KW-2450 free base selectively binds to and inhibits the activities of IGF-1R and IR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-R1 and IR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in the stimulation of cellular proliferation, oncogenic transformation, and suppression of apoptosis.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Angiogenesis
Target

IGF-1R
Recptor

IGF-1R
Research Area

——
Indication

——

CAS Number

904899-25-8
Formula Weight

515.63
Molecular Formula

C28H29N5O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

C(=C/C1=C(NC(=O)C=2SC=CC2C)C=C(CN3CCN(C(CO)=O)CC3)C=C1)\C=4C=5C(NN4)=CC=CC5
Chemical Name

——