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MSC-2530818
CAS No. 1883423-59-3
MSC-2530818( MSC 2530818 | MSC2530818 )
Catalog No. M12925 CAS No. 1883423-59-3
MSC-2530818 (MSC 2530818, MSC2530818) is a potent, selective, and orally bioavailable CDK8 inhibitor with IC50 of 2.6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 132 | Get Quote |
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| 10MG | 218 | Get Quote |
|
| 25MG | 482 | Get Quote |
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| 50MG | 696 | Get Quote |
|
| 100MG | 972 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameMSC-2530818
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NoteResearch use only, not for human use.
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Brief DescriptionMSC-2530818 (MSC 2530818, MSC2530818) is a potent, selective, and orally bioavailable CDK8 inhibitor with IC50 of 2.6 nM.
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DescriptionMSC-2530818 (MSC 2530818, MSC2530818) is a potent, selective, and orally bioavailable CDK8 inhibitor with IC50 of 2.6 nM; binds to CDK8 and CDK19 with similar affinity (4 nM), and displays good selectivity profile in a 264 kinase panel with exception of GSK3α (IC50=691 nM); potently inhibits of phospho-STAT1 S727 in SW620 cells (IC50=8 nM), shows potent inhibition of WNT-dependent transcription in human cancer cell lines; demonstrates tumor growth inhibition in an APC mutant SW620 human colorectal carcinoma xenograft model.
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In Vitro——
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In Vivo——
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SynonymsMSC 2530818 | MSC2530818
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1883423-59-3
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Formula Weight340.811
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Molecular FormulaC18H17ClN4O
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 125 mg/mL 366.77 mM
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SMILESO=C(N1[C@H](C2=CC=C(Cl)C=C2)CCC1)C3=CN=C(NN=C4C)C4=C3
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Chemical Name[(2S)-2-(4-Chlorophenyl)pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Czodrowski P, et al. J Med Chem. 2016 Oct 27;59(20):9337-9349.
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