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IIIM-290
CAS No. 2213468-64-3
IIIM-290( IIIM290 )
Catalog No. M13528 CAS No. 2213468-64-3
IIIM-290 is a potent, orally active cyclin-dependent kinase (CDK) inhiitor with IC50 of 1.9 and 16 nM for Cdk-9/T1 and Cdk-2/A, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1143 | Get Quote |
|
| 50MG | 2322 | Get Quote |
|
| 100MG | 3060 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameIIIM-290
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NoteResearch use only, not for human use.
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Brief DescriptionIIIM-290 is a potent, orally active cyclin-dependent kinase (CDK) inhiitor with IC50 of 1.9 and 16 nM for Cdk-9/T1 and Cdk-2/A, respectively.
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DescriptionIIIM-290 is a potent, orally active cyclin-dependent kinase (CDK) inhiitor with IC50 of 1.9 and 16 nM for Cdk-9/T1 and Cdk-2/A, respectively; selectively inhibits Molt-4/MIAPaCa-2 cell growth with GI50 of <1 uM; inhibits the cell growth of MIAPaCa-2 cells via caspase-dependent apoptosis, demonstrates in vivo efficacy in pancreatic, colon, and leukemia xenografts at 50 mg/kg, po., without CYP/efflux-pump liability, and mutagenic/genotoxic or cardiotoxic effects.
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In Vitro——
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In Vivo——
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SynonymsIIIM290
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number2213468-64-3
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Formula Weight462.323
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Molecular FormulaC23H21Cl2NO5
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Purity>98% (HPLC)
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Solubility——
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SMILESOC1=C2C(OC(/C=C/C3=C(Cl)C=CC=C3Cl)=CC2=O)=C([C@]4([H])[C@H](O)CN(C)CC4)C(O)=C1
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Chemical Name(1'R,2'S)-2-(2,6-Dichlorostyryl)-5,7-dihydroxy-8-(3-hydroxy-1- methylpiperidin-4-yl)-4H-chromen-4-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bharate SB, et al. J Med Chem. 2018 Feb 22;61(4):1664-1687.
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