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MRT-10

CAS No. 330829-30-6

MRT-10( MRT 10 )

Catalog No. M27665 CAS No. 330829-30-6

MRT 10 is a smoothened (Smo) receptor antagonist (an IC50 = 0.5 μM in HEK293 cells transiently expressing mouse Smo).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MRT-10
  • Note
    Research use only, not for human use.
  • Brief Description
    MRT 10 is a smoothened (Smo) receptor antagonist (an IC50 = 0.5 μM in HEK293 cells transiently expressing mouse Smo).
  • Description
    MRT 10 is a smoothened (Smo) receptor antagonist (an IC50 = 0.5 μM in HEK293 cells transiently expressing mouse Smo). It also inhibits bodipy-cyclopamine binding to the murine Smo receptor (an IC50 = 0.5 μM.
  • In Vitro
    MRT-10 inhibits the Smo-induced IP accumulation in a dosedependent manner (IC50=2.5 μM) in HEK293 cells.MRT-10 (10-9-10-5 M; 2 h) blocks Bodipy-cyclopamine (5 nM; 2 h) binding to cells expressing mouse Smo in a dosedependent manner with an IC50=0.5 μM.MRT-10 (10-9-10-5 M; 40 h) inhibits ShhN signaling in Shh-light2 cells in a dose-dependent manner with an IC50=0.64 μM.MRT-10 (10-9-10-5 M; 6 days) inhibits the SAG-induced (0.1 μM) alkaline phosphatase (AP) activity with an IC50=0.90 μM ) in C3H10T1/2 cells.
  • In Vivo
    ——
  • Synonyms
    MRT 10
  • Pathway
    GPCR/G Protein
  • Target
    Hedgehog (Hh)
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    330829-30-6
  • Formula Weight
    465.52
  • Molecular Formula
    C24H23N3O5S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (214.81 mM)
  • SMILES
    COc1cc(cc(OC)c1OC)C(=O)NC(=S)Nc1cccc(NC(=O)c2ccccc2)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Burov S, et al. Incorporation of N-amidino-pyroglutamic acid into peptides using intramolecular cyclization of alpha-guanidinoglutaric acid. J Pept Sci. 2009 Nov;15(11):760-6.
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