ML198( —— )

Catalog No. M23537 CAS No. 1380716-06-2

ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

ML198
Note

Research use only, not for human use.
Brief Description

ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase.
Description

ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase. ML198 serves as a starting point to develop a novel approach towards small molecule treatment for patients suffering from Gaucher disease.
In Vitro

ML198 is stable in D-PBS pH 7.4 at room temperature over 48 hr.ML198 increases translocation of GCase to the lysosome (20% cell translocation at 5 μM, compared to 5% of DMSO) in human fibroblasts.ML198 shows promising microsomal stability and Caco-2 permeability, with low water solubility.
In Vivo

——
Synonyms

——
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Glucokinase
Recptor

glucocerebrosidase
Research Area

——
Indication

——

Chemical Information

CAS Number

1380716-06-2
Formula Weight

290.32
Molecular Formula

C17H14N4O
Purity

>98% (HPLC)
Solubility

DMSO:Insoluble;Water:Insoluble
SMILES

CC1=CC(=NC2=C(C=NN12)C(=O)NC3=CC=C(C=C3)C#C)C
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Rogers S , Patnaik S , Schoenen F , et al. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase[M]. PubMed, 2010.

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