Cart
sales@molnova.com
Home - Products - Cytoskeleton/Cell Adhesion Molecules - Glucokinase - Hexestrol

Hexestrol

CAS No. 84-16-2

Hexestrol( Cycloestrol | Erythrohexestrol | Hexoestrol | HSDB 2149 )

Catalog No. M19165 CAS No. 84-16-2

Hexestrol binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
50MG 34 In Stock
100MG 42 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Hexestrol
  • Note
    Research use only, not for human use.
  • Brief Description
    Hexestrol binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.
  • Description
    Hexestrol is a synthetic ER agonist, microtubule polymerization inhibitor, and potential carcinogen. It induces mitotic arrest, aneuploidy, and DNA adduct formation.(In Vivo):Hexestrol (3 and 6 mg/kg; i.p. once daily for 30 days) has a not significant influence in the ovaries from mice at the dose of 3 mg/kg.
  • In Vitro
    ——
  • In Vivo
    Hexestrol (3 and 6 mg/kg; i.p. once daily for 30 days) has a not significant influence in the ovaries from mice at the dose of 3 mg/kg. Animal Model:Mus musculus (90-120 days, 25-50 g)Dosage:3, 6 mg/kg (adopted the same dose used to increase weight gain in cattle)Administration:I.p. once daily for 30 days Result:Numerous follicles in different stages of development were found at the dose of 3 mg/kg in the ovaries.Not detected the corpora lutea (CL) at the dose of 6 mg/kg.
  • Synonyms
    Cycloestrol | Erythrohexestrol | Hexoestrol | HSDB 2149
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Glucokinase
  • Recptor
    ERα| ERβ
  • Research Area
    Endocrinology
  • Indication
    ——

Chemical Information

  • CAS Number
    84-16-2
  • Formula Weight
    270.37
  • Molecular Formula
    C18H22O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (369.86 mM)
  • SMILES
    CC[C@@H]([C@@H](CC)C1=CC=C(O)C=C1)C1=CC=C(O)C=C1
  • Chemical Name
    4,4'-((3R,4S)-hexane-3,4-diyl)diphenol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Waibel M, et al. Eur J Med Chem, 2009, 44(9), 3412-3424.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • AZ6102

    AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells.

  • Kaempferol 3-gentiob...

    Kaempferol 3-O-gentiobioside is a flavonoid isolated from C. alata leaves with antidiabetic activity. It possesses activity against α-glucosidase and displays a carbohydrate enzyme inhibitory effect (IC50: 50 μM).

  • Dexamethasone palmit...

    Dexamethasone palmitate, a lipophilic prodrug of Dexamethasone, shows a 47-fold lower affinity for the glucocorticoid receptor than Dexamethasone.

Sign In Join Free