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ML-148
CAS No. 451496-96-1
ML-148( —— )
Catalog No. M28159 CAS No. 451496-96-1
ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 170 | Get Quote |
|
| 10MG | 267 | Get Quote |
|
| 25MG | 483 | Get Quote |
|
| 50MG | 698 | Get Quote |
|
| 100MG | 972 | Get Quote |
|
| 500MG | 1953 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameML-148
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NoteResearch use only, not for human use.
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Brief DescriptionML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM).
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DescriptionML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM). ML-148 can be used to profile across a panel of related dehydrogenase or reductase enzymes and in studies about prostaglandin-signaling pathways.(In Vitro):ML148 (10 nM) reduces the apparent Km by half and decreases Vmax by 25%. ML148 shows selectivity with IC50s of 36000, >57500, >57500 nM for ALDH1A1, HADH2, HSD17β4, respectively.
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In VitroML148 (compound 13) shows selectivity with IC50s of 56, 36000, >57500, >57500 nM for 15-PGDH, ALDH1A1, HADH2, HSD17β4, respectively.ML148 (10, 20 nM) decrease Vmax by 25% and reduces the apparent Km by half at a concentration of 10 nM.
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetDehydrogenase
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RecptorGPR52
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Research Area——
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Indication——
Chemical Information
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CAS Number451496-96-1
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Formula Weight319.4
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Molecular FormulaC20H21N3O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (156.54 mM)
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SMILESO=C(C=1C=CC2=C(N=CN2C3=CC=CC(=C3)C)C1)N4CCCCC4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Wang, C., Zhang, Y.-F., Guo, S., et al.GPR52 antagonist reduces huntingtin levels and ameliorates Huntington’s disease-related phenotypesJ. Med. Chem.64(2)941-957(2021)
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