MK-7288( MK7288 | MK 7288 )

Catalog No. M16708 CAS No. 936626-07-2

COA

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Product Name

MK-7288
Note

Research use only, not for human use.
Brief Description

A novel histamine H3 receptor inverse agonist for the treatment of sleep apnoea syndrome.
Description

A novel histamine H3 receptor inverse agonist for the treatment of sleep apnoea syndrome; significantly prolongs MWT sleep latency, and improves car driving simulation standard deviation of lane position in clinical trials.Sleep Disorder Phase 1 Clinical.
In Vitro

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In Vivo

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Synonyms

MK7288 | MK 7288
Pathway

GPCR/G Protein
Target

Histamine Receptor
Recptor

Histamine Receptor
Research Area

Neurological Disease
Indication

Sleep Disorder

CAS Number

936626-07-2
Formula Weight

401.507
Molecular Formula

C22H31N3O4
Purity

>98% (HPLC)
Solubility

——
SMILES

CN(CCN1CCCCC1)C(=O)C2CCC3(CC2)C4=C(C(=O)O3)N=C(C=C4)OC
Chemical Name

(1r,4r)-2'-methoxy-N-methyl-7'-oxo-N-(2-(piperidin-1-yl)ethyl)-7'H-spiro[cyclohexane-1,5'-furo[3,4-b]pyridine]-4-carboxamide

1. Sun H, et al. J Clin Pharmacol. 2013 Dec;53(12):1294-302.

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