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Amodiaquine hydrochloride
CAS No. 6398-98-7
Amodiaquine hydrochloride( —— )
Catalog No. M15431 CAS No. 6398-98-7
A 4-aminoquinoline compound with anti-inflammatory properties.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 32 | In Stock |
|
| 100MG | 45 | In Stock |
|
| 200MG | 68 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAmodiaquine hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA 4-aminoquinoline compound with anti-inflammatory properties.
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DescriptionA 4-aminoquinoline compound with anti-inflammatory properties. (In Vitro):Amodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH+ neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells.(In Vivo):Amodiaquine (40 mg/kg; intraperitoneal injection; daily; for 3 days; male ICR mice) treatment diminishes perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppresses ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice.
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In VitroAmodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH+ neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells. RT-PCR Cell Line:Primary microglia Concentration:10 μM, 15 μM, 20 μM Incubation Time:4 hours Result:Suppressed LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.
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In VivoAmodiaquine (40 mg/kg; intraperitoneal injection; daily; for 3 days; male ICR mice) treatment diminishes perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppresses ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice. Animal Model:Male ICR mice (8-10?weeks of age) induced ntracerebral hemorrhage (ICH) Dosage:40 mg/kg Administration:Intraperitoneal injection; daily; for 3 days Result:Diminished perihematomal activation of microglia/macrophages and astrocytes.
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Synonyms——
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PathwayGPCR/G Protein
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TargetHistamine Receptor
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Recptorhistamine N-methyl transferase
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Research AreaInfection
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Indication——
Chemical Information
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CAS Number6398-98-7
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Formula Weight464.82
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Molecular FormulaC20H28Cl3N3O3
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Purity>98% (HPLC)
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SolubilityWater: 10 mM
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SMILESO.O.Cl.Cl.CCN(CC)CC1=C(O)C=CC(NC2=C3C=CC(Cl)=CC3=NC=C2)=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.de Villiers KA, et al. J Inorg Biochem. 2008 Aug;102(8):1660-7.
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