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Hydroxyzine free base

CAS No. 68-88-2

Hydroxyzine free base( —— )

Catalog No. M22598 CAS No. 68-88-2

Hydroxyzine is an antagonist of histamine H1-receptor. Hydroxyzine is an antihistaminic with sedative properties used in the control of anxiety and emesis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Hydroxyzine free base
  • Note
    Research use only, not for human use.
  • Brief Description
    Hydroxyzine is an antagonist of histamine H1-receptor. Hydroxyzine is an antihistaminic with sedative properties used in the control of anxiety and emesis.
  • Description
    Hydroxyzine is an antagonist of histamine H1-receptor. Hydroxyzine is an antihistaminic with sedative properties used in the control of anxiety and emesis.
  • In Vitro
    Hydroxyzine dihydrochloride inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min.
  • In Vivo
    Hydroxyzine dihydrochloride (12.5 mg/kg, 25 mg/kg and 50 mg/kg i.p.) shows little direct analgesic activity but markedly potentiates only the effect of morphine on the vocalization after-discharge which represents the affective component of pain in rats. Hydroxyzine dihydrochloride (50 mg/kg i.p.) potentiates morphine on the tail-flick test, while Hydroxyzine (12.5 mg/kg i.p.) decreases morphine antinociception in rats.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Histamine Receptor
  • Recptor
    H1 receptor
  • Research Area
    nervous system
  • Indication
    Agitation on Recovery From Sedation

Chemical Information

  • CAS Number
    68-88-2
  • Formula Weight
    374.9
  • Molecular Formula
    C21H27ClN2O2?
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (266.74 mM)
  • SMILES
    OCCOCCN1CCN(CC1)C(c1ccccc1)c1ccc(Cl)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mcintyre I M , Mallett P , Trochta A , et al. Hydroxyzine distribution in postmortem cases and potential for redistribution[J]. Forensic ence International, 2013, 231(1-3):28-33.
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