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MB05032

CAS No. 261365-11-1

MB05032( —— )

Catalog No. M33427 CAS No. 261365-11-1

MB05032 is a potent fructose-,-bisphosphatase inhibitor that inhibits gluconeogenesis and reduces d-lactate-triggered ETosis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MB05032
  • Note
    Research use only, not for human use.
  • Brief Description
    MB05032 is a potent fructose-,-bisphosphatase inhibitor that inhibits gluconeogenesis and reduces d-lactate-triggered ETosis.
  • Description
    MB05032 is a special and efficacious gluconeogenesis inhibitor targeted the AMP binding site of fructose 1,6-bisphosphatase (FBPase) with an IC50 value of 16 nM.
  • In Vitro
    ——
  • In Vivo
    Animal Model:ZDF rats (8- to 9-week-old (mild diabetes) and 12- to 13-week-old (overt diabetes))Dosage:3, 6, 10, 30, 300 mg/kg (young ZDF rats); 6, 10, 30, 300 mg/kg (aged ZDF rats) Administration:Oral administration; once Result:Results in dose-dependent glucose lowering.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Phosphatase
  • Recptor
    Phosphatase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    261365-11-1
  • Formula Weight
    302.29
  • Molecular Formula
    C11H15N2O4PS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (165.40 mM; Ultrasonic )
  • SMILES
    O=P(O)(O)C=1OC(=CC1)C=2N=C(SC2CC(C)C)N
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Erion MD, et al. MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes. Proc Natl Acad Sci U S A. 2005 May 31;102(22):7970-5.?
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