sHNG, [Gly14] - HN, [Gly14] – Humanin

Research use only, not for human use.

(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions.

(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions.

Cell Viability Assay Cell Line:Human umbilical vein endothelial cells (HUVECs)，Concentration:100 nM, 1 μM and 10 μM Incubation Time:Pretreatment 3 hours and then treated with 72 hours Result:Significantly increased cell viability.Western Blot Analysis Cell Line:Human umbilical vein endothelial cells (HUVECs)，Concentration:1 μM Incubation Time:Pretreatment 3 hours and then treated with 72 hours Result:Reduced the ratio of bax/bcl-2.

Animal Model:Adult male CD-1 mice (25-30 g; 10-12-week-old) bearing traumatic brain injury (TBI) Dosage:0.1 μg/5 μL Administration:Intracerebroventricularly (i.c.v.); once Result:Decreased cells with plasmalemma permeability in the injured cortex and hippocampus, reduced brain lesion volume, improved motor performance.

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Others

Other Targets

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330936-70-4

2657.25

C118H202N34O31S2

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years