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sHNG, [Gly14] - HN, [Gly14] – Humanin

CAS No. 330936-70-4

sHNG, [Gly14] - HN, [Gly14] – Humanin( ——— )

Catalog No. M41854 CAS No. 330936-70-4

(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    sHNG, [Gly14] - HN, [Gly14] – Humanin
  • Note
    Research use only, not for human use.
  • Brief Description
    (Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions.
  • Description
    (Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions.
  • In Vitro
    Cell Viability Assay Cell Line:Human umbilical vein endothelial cells (HUVECs)，Concentration:100 nM, 1 μM and 10 μM Incubation Time:Pretreatment 3 hours and then treated with 72 hours Result:Significantly increased cell viability.Western Blot Analysis Cell Line:Human umbilical vein endothelial cells (HUVECs)，Concentration:1 μM Incubation Time:Pretreatment 3 hours and then treated with 72 hours Result:Reduced the ratio of bax/bcl-2.
  • In Vivo
    Animal Model:Adult male CD-1 mice (25-30 g; 10-12-week-old) bearing traumatic brain injury (TBI) Dosage:0.1 μg/5 μL Administration:Intracerebroventricularly (i.c.v.); once Result:Decreased cells with plasmalemma permeability in the injured cortex and hippocampus, reduced brain lesion volume, improved motor performance.
  • Synonyms
    ———
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ———
  • Research Area
    ———
  • Indication
    ———

Chemical Information

  • CAS Number
    330936-70-4
  • Formula Weight
    2657.25
  • Molecular Formula
    C118H202N34O31S2
  • Purity
    >98% (HPLC)
  • Solubility
    ———
  • SMILES
    ———
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ying Xie, et al. Protection effect of Gly14-Humanin from apoptosis induced by high glucose in human umbilical vein endothelial cells. Diabetes Res Clin Pract. 2014 Dec;106(3):560-6. ?
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