SR4 is a uncoupler of mitochondrial oxidative phosphorylation. SR4 modulating amp-dependent kinase (ampk)-mammalian target of rapamycin (mtor) signaling, and inhibiting proliferation of hepg2 hepatocarcinoma cellsSR4 is a novel mitochondrial uncoupler with anti-obesity and anti-diabetic properties.?

ISOBERGAPTEN is a plant growth regulating substance it is the principal constituents responsible for the antimycobacterial activity of the roots of Heracleum maximum;?it may form an important class of natural defensive agents against fungi.

Glucagon is a peptide hormone, produced by pancreatic α-cells. Glucagon reduces the activity of HNF-4. Glucagon stimulates gluconeogenesis. Glucagon enhances HNF4α phosphorylation.