Glucagon (1-29), bovine, human, porcine( —— )

Catalog No. M33370 CAS No. 16941-32-5

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Product Name

Glucagon (1-29), bovine, human, porcine
Note

Research use only, not for human use.
Brief Description

Glucagon is a peptide hormone, produced by pancreatic α-cells. Glucagon reduces the activity of HNF-4. Glucagon stimulates gluconeogenesis. Glucagon enhances HNF4α phosphorylation.
Description

Glucagon (1-29), bovine, human, porcine is a peptide hormone, produced by pancreatic α-cells. Glucagon stimulates gluconeogenesis. Glucagon (1-29), bovine, human, porcine activates HNF4α and increases HNF4α phosphorylation.
In Vitro

Western Blot Analysis Cell Line:Human primary hepatocytes (H1211, HH1215) Concentration:100 nM Incubation Time:Result:Resulted in a marked increase in the amount of phosphorylated HNF4α.
In Vivo

Animal Model:C57BL/6J mice (12- to 24-week-old) Dosage:20 μg/kg and 1 mg/kg Administration:Administered by i.p. injection; 45 minutes Result:Low-dose (20 μg/kg) increased glycemia and did not stimulate insulin secretion.High-dose (1 mg/kg) lowered glycemia and stimulated insulin secretion.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

CAS Number

16941-32-5
Formula Weight

3482.75
Molecular Formula

C153H225N43O49S
Purity

>98% (HPLC)
Solubility

In Vitro:?H2O : 6.67 mg/mL (1.92 mM; Ultrasonic; (HCL ，pH≈3) DMSO : 2 mg/mL (0.57 mM; Ultrasonic）
SMILES

C([C@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=C(O)C=C3)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC4=CC=CC=C4)NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](CC5=CN=CN5)N)=O)CO)=O)CCC(N)=O)=O)=O)[C@@H](C)O)=O)=O)[C@@H](C)O)=O)CO)=O)CC(O)=O)=O)=O)CO)=O)CCCCN)=O)=O)CC(C)C)=O)CC(O)=O)=O)CO)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)C)=O)CCC(N)=O)=O)CC(O)=O)=O)=O)C(C)C)=O)CCC(N)=O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]([C@@H](C)O)C(O)=O)=O)CC(N)=O)=O)CCSC)=O)CC(C)C)=O)C=6C=7C(NC6)=CC=CC7
Chemical Name

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1. Song WJ, et al. Glucagon regulates hepatic kisspeptin to impair insulin secretion. Cell Metab. 2014 Apr 1;19(4):667-81.?

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