Glucagon (1-29), bovine, human, porcine

Research use only, not for human use.

Glucagon is a peptide hormone, produced by pancreatic α-cells. Glucagon reduces the activity of HNF-4. Glucagon stimulates gluconeogenesis. Glucagon enhances HNF4α phosphorylation.

Glucagon (1-29), bovine, human, porcine is a peptide hormone, produced by pancreatic α-cells. Glucagon stimulates gluconeogenesis. Glucagon (1-29), bovine, human, porcine activates HNF4α and increases HNF4α phosphorylation.

Western Blot Analysis Cell Line:Human primary hepatocytes (H1211, HH1215) Concentration:100 nM Incubation Time:Result:Resulted in a marked increase in the amount of phosphorylated HNF4α.

Animal Model:C57BL/6J mice (12- to 24-week-old) Dosage:20 μg/kg and 1 mg/kg Administration:Administered by i.p. injection; 45 minutes Result:Low-dose (20 μg/kg) increased glycemia and did not stimulate insulin secretion.High-dose (1 mg/kg) lowered glycemia and stimulated insulin secretion.

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Others

Other Targets

Others

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16941-32-5

3482.75

C153H225N43O49S

>98% (HPLC)

In Vitro:?H2O : 6.67 mg/mL (1.92 mM; Ultrasonic; (HCL ，pH≈3) DMSO : 2 mg/mL (0.57 mM; Ultrasonic）

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(-20℃)

With Ice Pack

≥ 2 years