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Kisspeptin-13 (human)
CAS No. 374675-18-0
Kisspeptin-13 (human)( ——— )
Catalog No. M39986 CAS No. 374675-18-0
Kisspeptin 13 inhibits glucose-induced insulin secretion with an IC50 of 1.2 nM. Kisspeptin 13 activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
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Biological Information
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Product NameKisspeptin-13 (human)
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NoteResearch use only, not for human use.
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Brief DescriptionKisspeptin 13 inhibits glucose-induced insulin secretion with an IC50 of 1.2 nM. Kisspeptin 13 activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research.
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DescriptionKisspeptin 13 is a GPR54 and GnRH receptor activator, an endogenous active isoform. Kisspeptin 13 enhances memory and can be used in Alzheimer's disease research.
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In Vitro———
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In VivoKisspeptin 13 (intracerebroventricular administration; 2 μg/side; once) treatment improves object recognition memory impairment induced by Aβ through activation of GPR54 and GnRH receptor.Animal Model:Male Swiss mice with memory impairment induced by A-beta Dosage:2 μg/side Administration:Intracerebroventricular administration; 2 μg/side; once Result:Facilitated memory formation and prolonged memory retention through activation of the GPR54 and GnRH receptors, and suppressed memory-impairing effect of Aβ through activation of the GPR54.
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Synonyms———
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PathwayOthers
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TargetOther Targets
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Recptor———
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Research Area———
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Indication———
Chemical Information
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CAS Number374675-18-0
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Formula Weight1626.85
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Molecular FormulaC78H107N21O18
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Purity>98% (HPLC)
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Solubility———
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jiang JH, et al. Kisspeptin-13 enhances memory and mitigates memory impairment induced by Aβ1-42 in mice novel object and object location recognition tasks. Neurobiol Learn Mem. 2015 Sep;123:187-95.?
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