KL-50 is a selective toxin toward tumors that lack the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O6-alkylguanine lesions. KL-50 activates DNA damage response pathways and cycle arrest in MGMT-cells, independent of mismatch repair (MMR). KL-50 is promising for research of brain tumors that lack the DNA repair protein MGMT.

1,5-diphenylpyrazole-3-carboxylic acid is a plant-physiologically tolerable salt radical or any desired ester radical.

PK68 is an effective and selective inhibitor of type II receptor-interacting kinase 1 (RIPK1, IC50 = 90?nM). PK68 can be used for research on the treatment of inflammatory disorders and cancer metastasis.