Sibeprenlimab (VIS649) is a humanized IgG2 monoclonal antibody that inhibits APRIL and may be investigated for the prevention and treatment of kidney disease (IgAN).

Choline bitartrate is a form of the nutrient choline which is found in foods. Choline is necessary for normal liver and kidney function and a component of the neurotransmitter acetylcholine, a chemical that facilitates communication between the nerves and muscles.

Cucurbitacin B 2-o-α2-D-glucoside has anticancer activity.