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5-HT2B antagonist-1
CAS No. 393129-91-4
5-HT2B antagonist-1( —— )
Catalog No. M37679 CAS No. 393129-91-4
5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 of 33.4 nM, suitable for studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease, or gastrointestinal disease .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
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| 10MG | 36 | In Stock |
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| 25MG | 65 | In Stock |
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| 50MG | 112 | In Stock |
|
| 100MG | 186 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 458 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Name5-HT2B antagonist-1
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NoteResearch use only, not for human use.
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Brief Description5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 of 33.4 nM, suitable for studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease, or gastrointestinal disease .
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Description5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1 can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease.
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In Vitro5-HT2B antagonist-1 (compound 5g) has some sodium channel binding activity with IC50 values in the range of 12.6 to 57.5 μM.5-HT2B antagonist-1 (coumpound 1-e) inhibits 5-HT2B receptor activity by less than 50% at 1 μM in CHO-K1 cell lines.
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In Vivo5-HT2B antagonist-1 (compound 15) (oral gavage, 30 mg/kg) can reduce visceral hypersensitivity significantly in irritable bowel syndrome (IBS) rats.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number393129-91-4
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Formula Weight296.17
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Molecular FormulaC11H14BrN5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 33.33 mg/mL (112.54 mM; ) H2O : 12.5 mg/mL (42.21 mM; Ultrasonic (<60°C))
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SMILESCC1(C)NC(Nc2ccc(Br)cc2)=NC(N)=N1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Xiang Ma, et al. Synthesis and in vitro evaluation of 2,4-diamino-1,3,5-triazine derivatives as neuronal voltage-gated sodium channel blockers. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5644?
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