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5-HT2B antagonist-1

CAS No. 393129-91-4

5-HT2B antagonist-1( —— )

Catalog No. M37679 CAS No. 393129-91-4

5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 of 33.4 nM, suitable for studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease, or gastrointestinal disease .

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 28 In Stock
10MG 36 In Stock
25MG 65 In Stock
50MG 112 In Stock
100MG 186 In Stock
200MG Get Quote In Stock
500MG 458 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    5-HT2B antagonist-1
  • Note
    Research use only, not for human use.
  • Brief Description
    5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 of 33.4 nM, suitable for studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease, or gastrointestinal disease .
  • Description
    5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1 can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease.
  • In Vitro
    5-HT2B antagonist-1 (compound 5g) has some sodium channel binding activity with IC50 values in the range of 12.6 to 57.5 μM.5-HT2B antagonist-1 (coumpound 1-e) inhibits 5-HT2B receptor activity by less than 50% at 1 μM in CHO-K1 cell lines.
  • In Vivo
    5-HT2B antagonist-1 (compound 15) (oral gavage, 30 mg/kg) can reduce visceral hypersensitivity significantly in irritable bowel syndrome (IBS) rats.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    393129-91-4
  • Formula Weight
    296.17
  • Molecular Formula
    C11H14BrN5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 33.33 mg/mL (112.54 mM; ) H2O : 12.5 mg/mL (42.21 mM; Ultrasonic (<60°C))
  • SMILES
    CC1(C)NC(Nc2ccc(Br)cc2)=NC(N)=N1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Xiang Ma, et al. Synthesis and in vitro evaluation of 2,4-diamino-1,3,5-triazine derivatives as neuronal voltage-gated sodium channel blockers. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5644?
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