Swainsonine

Research use only, not for human use.

Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity.

Swainsonine is an alkaloid isolated from Astragalus, acts as an inhibitor of α-mannosidase, with anti-tumor activity.

Cell Viability Assay Cell Line:U251, LN444 cells Concentration:0, 10, 20, 30, 40 μM Incubation Time:12 h Result:Inhibited cell viability in a dose-dependent manner, and shows no cytotoxicity in normal brain cells.Cell Cycle Analysis Cell Line:U251 cells Concentration:30 μM Incubation Time:12 h Result:Induced cell cycle arrest at G2/M phase.Apoptosis Analysis Cell Line:U251 cells Concentration:30 μM Incubation Time:12 h Result:Induced apoptosis with the cleaved-Caspase-3 and cleaved-Caspase-9 expression were obviously increased.

Animal Model:Eighty-seven sixty-day-old male C57BL/6 mice Dosage:1 mg/kg (cisplatin; 0.25 mg/kg, i.p., every other day for 10 days) Administration:I.p.; twice daily for ten days Result:Showed a significant reduction in ascites volume of 63.5% was observed in mice and a significant reduction in the percentage of cells in the G0/G1, S and G2 phases.

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Others

Other Targets

α-mannosidase

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72741-87-8

173.21

C8H15NO3

>98% (HPLC)

DMSO : 10 mg/mL (57.73 mM; ultraphonic; ) Ethanol : 10 mg/mL (57.73 mM; ultraphonic)

OC1CN2CCCC(O)C2C1O

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(-20℃)

With Ice Pack

≥ 2 years