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TMX-4100
CAS No. 2367619-63-2
TMX-4100( ——— )
Catalog No. M39457 CAS No. 2367619-63-2
TMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. TMX-4100 shows a high degradation preference for PDE6D with the DC50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4100 can be used for the research of multiple myeloma.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 258 | In Stock |
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| 5MG | 235 | In Stock |
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| 10MG | 376 | In Stock |
|
| 25MG | 692 | In Stock |
|
| 50MG | 918 | In Stock |
|
| 100MG | 1293 | In Stock |
|
| 200MG | 1739 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTMX-4100
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NoteResearch use only, not for human use.
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Brief DescriptionTMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. TMX-4100 shows a high degradation preference for PDE6D with the DC50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4100 can be used for the research of multiple myeloma.
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DescriptionTMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. TMX-4100 shows a high degradation preference for PDE6D with the DC50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4100 can be used for the research of multiple myeloma.
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In VitroWestern Blot Analysis Cell Line:MOLT4 cells Concentration:1 μM Incubation Time:4 hours Result:Showed a high degradation preference for PDE6D.Western Blot Analysis Cell Line:MOLT4, Jurkat, and MM.1S cells Concentration:0 nM, 40 nM, 200 nM, 1 μM;Incubation Time:4 hours Result:Showed a high degradation preference for PDE6D with the DC50 value less than 200 nM.
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In Vivo———
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Synonyms———
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PathwayOthers
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TargetOther Targets
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RecptorPDE6D
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Research Area———
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Indication———
Chemical Information
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CAS Number2367619-63-2
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Formula Weight262.29
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Molecular FormulaC11H10N4O2S
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Purity>98% (HPLC)
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SolubilityDMSO : 100 mg/mL (381.25 mM; ultraphonic (<60°C); )
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Teng M, et al. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65(1):747-756.?
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