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13-Oxyingenol dodecanoat

CAS No. 54706-70-6

13-Oxyingenol dodecanoat( ——— )

Catalog No. M38697 CAS No. 54706-70-6

13-Oxyingenol-dodecanoate (13OD) is a tumor suppressor agent. 13-Oxyingenol-dodecanoate has anti-HIV-1 activity with EC50 value of 33.7 nM.13-Oxyingenol-dodecanoate can induce the expression of ULK1 to effect mitochondrial dysfunction and cellular autophagy. 13-Oxyingenol-dodecanoate also increases the expression of BAX and suppresses the expression of BCL-2 to effect apoptosis.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    13-Oxyingenol dodecanoat
  • Note
    Research use only, not for human use.
  • Brief Description
    13-Oxyingenol-dodecanoate (13OD) is a tumor suppressor agent. 13-Oxyingenol-dodecanoate has anti-HIV-1 activity with EC50 value of 33.7 nM.13-Oxyingenol-dodecanoate can induce the expression of ULK1 to effect mitochondrial dysfunction and cellular autophagy. 13-Oxyingenol-dodecanoate also increases the expression of BAX and suppresses the expression of BCL-2 to effect apoptosis.
  • Description
    Dodecanoic acid ingenol ester, a natural compound, shows moderate cytotoxicity with IC50 values being 35.59 μM (Caco-2), 24.04 μM (MCF-7), and 22.24 μM (MCF-7/ADM).
  • In Vitro
    Cell Viability Assay Cell Line:A549 and H460 cells Concentration:0, 3.125, 6.25, 12.5, 25, and 50 μM Incubation Time:72 h Result:Increased significantly the antitumor activity of A549 and H460 cells.Western Blot Analysis Cell Line:A549 and H460 cells Concentration:0, 5, 10, 20 μM Incubation Time:72 h Result:Induced significant up-regulation of ATG5, degradation of p62, and dose-dependent conversion of LC3 I to LC3 II.
  • In Vivo
    Animal Model:xenograft model by injecting H460 cells into nude mice Dosage:2.5 mg/kg and 5 mg/kg; every two days for two weeks Administration:Intraperitoneal injection (i.p.)Result:nhibited the growth of transplanted tumors in nude mice and had no significant toxic effects on organ function.
  • Synonyms
    ———
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ———
  • Indication
    ———

Chemical Information

  • CAS Number
    54706-70-6
  • Formula Weight
    546.745
  • Molecular Formula
    C32H50O7
  • Purity
    >98% (HPLC)
  • Solubility
    ———
  • SMILES
    ———
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Liu Q, et al. Identification, structural modification, and dichotomous effects on human immunodeficiency virus type 1 (HIV-1) replication of ingenane esters from Euphorbia kansui. Eur J Med Chem. 2018 Aug 5;156:618-627.?
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