Isoprocurcumenol

Research use only, not for human use.

Isoprocurcumenol is a guaiane type sesquiterpene, that can be isolated from Curcuma comosa. Isoprocurcumenol can activate EGFR signaling. Isoprocurcumenol increases the phosphorylation of ERK and AKT. Isoprocurcumenol promotes the proliferation of keratinocytes.

Isoprocurcumenol is an inhibitor of Nitric Oxide.

Western Blot Analysis Cell Line:HaCaT cells (human keratinocyte cell) Concentration:10 μM Incubation Time:10, 30, or 60 min Result:Induced the phosphorylation of ERK and AKT after 10 min and this was sustained for 1 h.Cell Proliferation Assay Cell Line:HaCaT cells (human keratinocyte cell) Concentration:0 nM, 1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 25 μM, 50 μM, 100 μM, or 200 μM Incubation Time:24 or 48 h Result:Showed a significant increase in the proliferation of cells at most of the Isoprocurcumenol concentrations, starting at 10 nM.RT-PCR Cell Line:HaCaT cells (human keratinocyte cell)Concentration:1 μM Incubation Time:1 h Result:Increased the expression of genes related to cell growth and proliferation, such as c-myc, c-jun, c-fos, and egr-1.

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Others

Other Targets

NO

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102130-90-5

234.33

C15H22O2

>98% (HPLC)

DMSO : 2.4 mg/mL (10.24 mM; ultraphonic; )

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(-20℃)

With Ice Pack

≥ 2 years